Product overview
Epithalon 50mg/10vials is a sterile lyophilized research peptide supplied at the higher-strength 50mg-per-vial configuration. Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide derived from work on the pineal extract epithalamin by researchers at the St. Petersburg Institute of Bioregulation and Gerontology, and has been studied across a long series of preclinical longevity, telomerase-activity, and pineal-axis endpoints.
Independently assayed by HPLC and MS, and lot-traceable. The 50mg-per-vial format is intended for protocols that require larger working volumes than the standard 10mg ET10 SKU.
Mechanism
Preclinical literature characterizes Epithalon activity around several distinct endpoints. The most-cited line of work reports upregulation of telomerase activity in human somatic cell cultures, with downstream effects on telomere length over multiple passages. A second line examines pineal-axis activity, with reported effects on the timing and amplitude of melatonin secretion in animal models. A third line investigates downstream effects on circadian gene expression.
The molecule has been included in long-running rodent longevity studies, where reported effects on mean and maximal lifespan endpoints have made it a recurring research tool in the field.
Typical research dose range
Published preclinical longevity protocols typically use Epithalon in animal models at quantities corresponding to roughly 0.1-1 mg/kg per administration, cycled across multi-week study windows. The exact protocol varies substantially between source publications.
Stack and pairing
Epithalon is frequently studied alongside SS-31 (mitochondrial oxidative-stress work), NAD+ (cellular bioenergetics), and DSIP (sleep-architecture and circadian endpoints) in multi-arm preclinical longevity protocols.
Reconstitution and storage
Reconstitute each vial with 1-2 mL of bacteriostatic water for the target working concentration. Use sterile technique. Once reconstituted, store at 2-8 °C and use within 30 days for best stability.
Lyophilized vials should be kept refrigerated at 2-8 °C until first use. For long-term storage beyond six months, store at -20 °C in the original sealed vial. Avoid repeated freeze-thaw cycles.
Kit contents
- 10 × 50mg vials of lyophilized Epithalon
- 1 × certificate of analysis (lot-specific)
- 1 × handling and reconstitution insert
Frequently asked questions
Is this product for human consumption?
No. This product is sold strictly for laboratory research use only. It is not a drug, food, cosmetic, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.
How does this 50mg SKU differ from the 10mg ET10 SKU?
It is the same molecule at five times the per-vial mass. The 50mg format reduces vial count for protocols that require larger working volumes; the 10mg ET10 SKU is more convenient for smaller protocols or for researchers who reconstitute one vial at a time.
Do you ship internationally?
This SKU ships from our Canadian fulfillment facility to addresses within Canada. International availability varies by region — see our shipping policy for current routing.
What is the shelf life of an unopened vial?
Properly stored at 2-8 °C in the original sealed vial, lyophilized Epithalon retains potency for 24 months from the date of manufacture. The expiration date is printed on each vial.
