What exactly is SS-31, and why do research programs pick the 50mg tier?
SS-31 (elamipretide) is a mitochondrial-targeted tetrapeptide with the sequence D-Arg-Dmt-Lys-Phe-NH2, studied in pre-clinical models for its selective binding to cardiolipin on the inner mitochondrial membrane. The 50mg per vial tier is unusually large for the SS-31 category — programs choose it when a running protocol needs several months of working stock without repeated vial changes, or when running dose-response curves that consume mass quickly.
What does this specific lot’s CoA cover?
Every SS-31 lot is independently assayed by reverse-phase HPLC for purity and by mass-spectrometry for identity against the theoretical mass of the D-amino-acid sequence. Lot-specific certificates of analysis are being catalogued and will be publicly listed on the product page as they come online.
How do I reconstitute a 50mg SS-31 vial?
- Wipe the vial stopper with an alcohol swab and let the alcohol flash off.
- Draw 1 to 2 mL of bacteriostatic water into a sterile syringe.
- Inject the diluent slowly against the vial wall so the stream does not disrupt the lyophilized cake.
- Roll the vial gently between the palms to dissolve. Do not shake — SS-31 is a small peptide but shear from vortexing is best avoided.
- Store the reconstituted vial at 2 to 8 °C and use within 30 days.
Why does mitochondrial research typically use higher-mass SS-31 vials?
SS-31 is used most often in extended time-course work — cardiolipin-remodeling studies, electron-transport-chain efficiency assays, and ischemia-reperfusion models frequently run for weeks and sample daily. Higher-mass vials cut down on reconstitution overhead and reduce lot-to-lot variance across a single experiment, which is why 50mg is treated as the extended-program tier rather than the standard entry size.
How does SS-31 compare with other mitochondrial-support molecules?
SS-31 is mechanistically distinct from small-molecule mitochondrial-support compounds. Its cardiolipin-binding tetrapeptide structure targets the inner membrane directly, whereas NAD-precursor molecules act upstream on cofactor pools. Research programs frequently pair SS-31 with an NAD-axis intervention such as NAD+ vials to separate membrane-level from cofactor-level effects in the same model.
What ships in the box, and how fast?
- 10 lyophilized SS-31 50mg vials
Orders placed before 14:00 PT ship the same business day from our British Columbia facility. Canadian orders arrive in 2 to 4 business days after dispatch.
