What exactly is NAD+, and where does the 500mg tier fit?
NAD+ (nicotinamide adenine dinucleotide, oxidised form) is the central cofactor in cellular redox reactions and the substrate that sirtuin and PARP enzymes consume during signalling and DNA-repair activity. It is not a peptide — it is a nucleotide-family coenzyme, catalogued here for the longevity, sirtuin, and mitochondrial-metabolism research programs it supports. The NJ500 500mg per vial tier is the high-mass presentation for longevity, sirtuin, and mitochondrial pre-clinical work that would otherwise require multiple small-vial reconstitutions.
What does this specific lot’s CoA cover?
Every lot is independently assayed by reverse-phase HPLC for purity and by mass-spec for identity against theoretical mass. Lot-specific certificates of analysis are being catalogued and will be publicly listed on the product page as they come online.
How do I reconstitute a 500mg NAD+ vial?
- Wipe the vial stopper with an alcohol swab.
- Draw 5 to 10 mL of bacteriostatic water (the 500mg mass requires higher diluent volume to dissolve cleanly; multi-mL injections may need to be split across two draws).
- Inject the diluent slowly against the vial wall — do not aim at the peptide cake.
- Swirl gently to dissolve. Do not shake. NAD+ dissolves readily but the large cake may need a minute or two of gentle rotation.
- Store the reconstituted vial at 2 to 8 °C. Use within 30 days.
Why the 500mg tier — is there a smaller size?
500mg per vial is currently the only NAD+ presentation stocked; smaller vial sizes are not carried today. The 500mg tier suits protocols that need meaningful working-solution volume for multi-week studies without recurring reconstitution overhead; downstream dilutions handle any working-concentration adjustment.
How is NAD+ different from adjacent longevity-axis research tools?
NAD+ is a coenzyme substrate — the molecule that sirtuins and PARPs directly consume — so it sits at the biochemistry layer of the longevity axis. Epithalon (ET10 / ET50) is a synthetic tetrapeptide studied as a telomerase modulator, mechanistically upstream of the aging phenotype rather than at the cofactor layer. MOTS-C (MS10 / MS20) is a 16-amino-acid mitochondrial-derived peptide signalling through AMPK. All three appear in longevity-axis pre-clinical programs, but they act at different mechanistic layers and are typically studied in parallel, not as substitutes.
What ships in the box, and how fast?
- 10 lyophilized NAD+ 500mg vials
- 1 lot-specific certificate of analysis (HPLC + MS)
- 1 handling and reconstitution insert
Orders placed before 14:00 PT ship the same business day from our British Columbia facility. Canadian orders arrive in 2 to 4 business days after dispatch.
