What exactly is MOTS-C, and where does the 20mg tier fit?
MOTS-C is a 16-amino-acid synthetic peptide encoded by mitochondrial DNA — a mitochondrial-derived peptide (MDP) studied in metabolic homeostasis and exercise-response research. Its mechanistic footprint runs through AMPK activation and mitochondrial-signalling pathways, distinct from receptor-agonist metabolic tools. The 20mg per vial tier is the extended-cohort or higher-concentration size — suited to studies that need multi-week working stocks from a single reconstitution, or programs where scaling to two 10mg vials per session would double reconstitution overhead.
What does this specific lot’s CoA cover?
Every lot is independently assayed by reverse-phase HPLC for purity and by mass-spec for identity against theoretical mass. Lot-specific certificates of analysis are being catalogued and will be publicly listed on the product page as they come online.
How do I reconstitute a 20mg MOTS-C vial?
- Wipe the vial stopper with an alcohol swab.
- Draw 2 to 3 mL of bacteriostatic water (target concentration determines volume — the higher-mass cake tolerates 2 to 3 mL cleanly).
- Inject the diluent slowly against the vial wall — do not aim at the peptide cake.
- Swirl gently to dissolve. Do not shake.
- Store the reconstituted vial at 2 to 8 °C. Use within 30 days.
Should I order the 10mg or 20mg tier?
Cohort size and study duration drive the choice. The 10mg tier (MS10) fits smaller studies, pilot dose-response designs, and any protocol where a reconstituted vial would be exhausted well before the 30-day post-reconstitution window closes. The 20mg tier suits studies that need multi-week working stocks from a single reconstitution — higher-throughput cohorts, longer-arm designs, or programs where reducing the number of reconstitution events per week matters for procedural consistency.
How is MOTS-C different from GLP-1-class metabolic peptides?
The mechanism route is the distinction. GLP-1-class metabolic peptides — Retatrutide, Tirzepatide, Semaglutide — signal through the incretin axis at the GLP-1 receptor (and GIP / glucagon receptors, depending on the specific molecule). MOTS-C signals independently of the incretin axis. Its research literature centres on AMPK activation and direct mitochondrial-signalling pathways as the mechanistic route into metabolic homeostasis. Programs comparing incretin-axis modulators against non-incretin mitochondrial-signalling tools frequently run MOTS-C alongside a GLP-1-class arm.
What ships in the box, and how fast?
- 10 lyophilized MOTS-C 20mg vials
- 1 lot-specific certificate of analysis (HPLC + MS)
- 1 handling and reconstitution insert
Orders placed before 14:00 PT ship the same business day from our British Columbia facility. Canadian orders arrive in 2 to 4 business days after dispatch.
