Product overview
Kisspeptin-10 10mg/10vials is a sterile lyophilized research peptide. Kisspeptin-10 is the 10-amino-acid C-terminal fragment of the parent KISS1 gene product and is the minimal sequence that retains full activity at the kisspeptin receptor (KISS1R, also called GPR54). The molecule is a foundational tool peptide in preclinical hypothalamic-pituitary-gonadal (HPG) axis research, where it is used to probe upstream regulation of gonadotropin-releasing hormone (GnRH) neurons.
Independently assayed by HPLC and MS, and lot-traceable to the source preparation.
Mechanism
Kisspeptin-10 binds KISS1R on hypothalamic GnRH neurons and triggers a sharp release of GnRH, which in turn drives downstream LH and FSH secretion from the anterior pituitary. The kisspeptin system is the dominant upstream control point for the HPG axis — its identification in the early 2000s reshaped the understanding of how the brain initiates puberty, regulates the menstrual cycle, and responds to metabolic state.
In preclinical models, kisspeptin-10 has been used to characterize the dynamics of GnRH pulse generation, the integration of metabolic signals (leptin, insulin) into reproductive control, and the receptor desensitization profile that distinguishes pulsatile from continuous KISS1R stimulation.
Typical research dose range
Published preclinical HPG-axis protocols use kisspeptin-10 across a wide range. Animal-model studies have used quantities in the range of roughly 1-10 mcg/kg per administration to evoke a measurable LH pulse, with the timing and pulse-pattern of administration being the most consequential variable. Researchers should consult source literature for the specific endpoint under investigation.
Stack and pairing
Kisspeptin-10 is studied alongside GHRH analogs and ghrelin-mimetic secretagogues in protocols that examine cross-talk between the HPG and somatotropic axes. It is also used in study designs that examine the integration of metabolic signals into reproductive control.
Reconstitution and storage
Reconstitute each vial with 1-2 mL of bacteriostatic water for the target working concentration. Use sterile technique. Once reconstituted, store at 2-8 °C and use within 30 days for best stability.
Lyophilized vials should be kept refrigerated at 2-8 °C until first use. For long-term storage beyond six months, store at -20 °C in the original sealed vial. Avoid repeated freeze-thaw cycles.
Kit contents
- 10 × 10mg vials of lyophilized Kisspeptin-10
- 1 × certificate of analysis (lot-specific)
- 1 × handling and reconstitution insert
Frequently asked questions
Is this product for human consumption?
No. This product is sold strictly for laboratory research use only. It is not a drug, food, cosmetic, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.
What is the difference between Kisspeptin-10 and longer kisspeptin fragments?
The parent KISS1 gene product is processed into several fragments — kisspeptin-54, -14, -13, and -10. Kisspeptin-10 is the shortest fragment that retains full activity at KISS1R, which makes it the standard tool peptide for receptor-pharmacology work. The longer fragments have similar intrinsic activity but different in-vivo pharmacokinetics.
Do you ship internationally?
This SKU ships from our Canadian fulfillment facility to addresses within Canada. International availability varies by region — see our shipping policy for current routing.
What is the shelf life of an unopened vial?
Properly stored at 2-8 °C in the original sealed vial, lyophilized Kisspeptin-10 retains potency for 24 months from the date of manufacture. The expiration date is printed on each vial.
