Product overview
CJC-1295 NO DAC 10mg/10vials is a sterile lyophilized research peptide. The molecule is a synthetic 29-amino-acid analog of growth-hormone-releasing hormone (GHRH 1-29) carrying four amino-acid substitutions that stabilize the peptide against dipeptidyl-peptidase-IV cleavage. The “no-DAC” designation indicates the absence of the drug-affinity-complex (maleimide) linker found in CJC-1295-DAC; that linker is responsible for albumin binding and the multi-day half-life of the DAC variant, so the no-DAC molecule has a much shorter pharmacokinetic window.
Independently assayed by HPLC and MS, and lot-traceable to the source preparation.
Mechanism
In preclinical models, CJC-1295 NO DAC binds the pituitary GHRH receptor and stimulates a short, sharp pulse of growth-hormone release that mirrors the natural pulsatile pattern of endogenous GHRH. Because the molecule lacks the DAC linker, the pulse profile is short — published half-life in animal models is on the order of 30 minutes — making it the preferred research tool when investigators want to probe individual GH pulses rather than tonic elevation.
It is frequently studied in combination with a growth-hormone secretagogue such as ipamorelin in protocols examining GH-pulse synergy.
Typical research dose range
Preclinical GH-axis protocols typically use CJC-1295 NO DAC in the 100 mcg per administration range in animal models, with the timing of administration aligned to the natural circadian GH-pulse pattern. Combination protocols with a ghrelin-mimetic secretagogue use comparable per-pulse quantities of each peptide.
Stack and pairing
CJC-1295 NO DAC is one half of the canonical “GHRH plus secretagogue” preclinical research pair. The most-studied counterpart is ipamorelin; tesamorelin is sometimes used as a longer-acting GHRH alternative in adjacent study designs. The combined-vial blend SKU CP10-nullMG-10V offers CJC + IPA in a single reconstitution.
Reconstitution and storage
Reconstitute each vial with 1-2 mL of bacteriostatic water for the target working concentration. Use sterile technique. Once reconstituted, store at 2-8 °C and use within 30 days for best stability.
Lyophilized vials should be kept refrigerated at 2-8 °C until first use. For long-term storage beyond six months, store at -20 °C in the original sealed vial. Avoid repeated freeze-thaw cycles.
Kit contents
- 10 × 10mg vials of lyophilized CJC-1295 NO DAC
- 1 × certificate of analysis (lot-specific)
- 1 × handling and reconstitution insert
Frequently asked questions
Is this product for human consumption?
No. This product is sold strictly for laboratory research use only. It is not a drug, food, cosmetic, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.
What is the difference between CJC-1295 NO DAC and CJC-1295 with DAC?
The DAC variant carries a maleimide linker that covalently binds circulating albumin, extending half-life to roughly 7-10 days in animal models. The no-DAC variant lacks the linker, giving a short ~30-minute half-life and a sharp single GH-release pulse — a different pharmacokinetic tool for different research questions.
Do you ship internationally?
This SKU ships from our Canadian fulfillment facility to addresses within Canada. International availability varies by region — see our shipping policy for current routing.
What is the shelf life of an unopened vial?
Properly stored at 2-8 °C in the original sealed vial, lyophilized CJC-1295 NO DAC retains potency for 24 months from the date of manufacture. The expiration date is printed on each vial.
