What exactly is Tesamorelin, and why do research programs pick the 10mg tier?
Tesamorelin is a synthetic 44-amino-acid analog of human growth-hormone-releasing hormone (GHRH), differentiated by a trans-3-hexenoyl group anchored at the N-terminus that shields the peptide from rapid proteolytic degradation. It has been studied extensively in pre-clinical GH-axis stimulation and body-composition research. The 10mg per vial tier gives enough peptide mass to hold a multi-week working stock at typical reconstitution volumes without dropping down to a single-dose format.
What does this specific lot’s CoA cover?
Every Tesamorelin lot is characterised by reverse-phase HPLC for peptide purity and by mass spectrometry against the theoretical 44-residue monoisotopic mass, with the N-terminal trans-3-hexenoyl modification confirmed. Lot-specific certificates of analysis are being catalogued and will appear on the product page as they clear release testing.
How do I reconstitute a 10mg Tesamorelin vial?
- Warm the vial to room temperature and swab the stopper with 70% isopropyl alcohol.
- Draw 1 to 2 mL of bacteriostatic water into a sterile syringe.
- Angle the needle so the diluent runs down the vial’s inner wall — do not pour it onto the cake.
- Roll gently between the palms until the peptide fully dissolves; a clear, colourless solution is expected.
- Refrigerate the reconstituted vial at 2 to 8 °C and use within 30 days.
Why the protease-resistant N-terminus matters
Native GHRH is cleaved rapidly by dipeptidyl peptidase-IV (DPP-IV) in plasma, which limits its useful signalling window in pre-clinical models. The trans-3-hexenoyl group added at Tesamorelin’s N-terminus blocks that cleavage, extending the GHRH-arm signal well beyond native GHRH without altering the underlying 44-amino-acid sequence. That stability is the reason Tesamorelin sees more use than raw GHRH(1-44) in longer-duration study designs.
How does Tesamorelin compare with CJC-1295 No-DAC and the TP15 blend?
CJC-1295 No-DAC (CND5) is a shorter 30-amino-acid GHRH backbone with a ~30-minute plasma half-life — better for tight pulse-amplitude experiments. Tesamorelin’s protease-resistant backbone gives a more stable GHRH signal across a longer window, which is why it is the GHRH partner in Prescott’s TP15 blend (Tesamorelin + Ipamorelin). Pick TSM10 for GHRH-only designs; move to TP15 when the study calls for a combined GHRH + GHS-R input in a single vial.
What ships in the box, and how fast?
- 10 lyophilized Tesamorelin 10mg vials
Orders placed before 14:00 PT dispatch same business day from Prescott Bio’s British Columbia warehouse; Canadian delivery is 2 to 4 business days after dispatch.
