Product overview
HGH 191AA 10iu/10vials is a sterile lyophilized preparation of recombinant human growth hormone (somatropin), synthesized as the full 191-amino-acid sequence in an E. coli expression system. Each vial contains 10 international units (approximately 3.3mg by mass at the standard 3.0 IU/mg conversion).
Independently assayed by HPLC and MS, and lot-traceable to the source preparation. Intended for preclinical research on the growth-hormone axis and downstream IGF-1 signaling.
Mechanism
Human growth hormone is a 191-amino-acid pituitary hormone that binds the growth-hormone receptor (GHR) on hepatic and peripheral target tissue. Receptor activation triggers JAK2/STAT5 signaling and downstream transcription of IGF-1, which mediates most of the downstream anabolic effects of GH on bone, muscle, and connective tissue. GH also has direct lipolytic activity at adipocyte GH receptors that is partially independent of the IGF-1 axis.
The recombinant 191AA preparation is the structurally complete form of the molecule — distinguished from older 192AA preparations (carrying an N-terminal methionine artifact of expression) that have largely been retired from research use.
Typical research dose range
Preclinical and clinical GH-axis literature uses recombinant human GH across a wide range depending on endpoint. Research-protocol exposures are typically reported in the 2-10 IU per administration range in animal models, with timing keyed to natural pulsatile patterns. Researchers should consult source literature for the specific endpoint under investigation.
Stack and pairing
Recombinant HGH is frequently studied alongside GHRH analogs (CJC-1295, tesamorelin) and ghrelin-mimetic secretagogues (ipamorelin) in protocols examining receptor-saturation kinetics and pulse-pattern interactions across the GH axis.
Reconstitution and storage
Reconstitute each vial with 1-2 mL of bacteriostatic water for the target working concentration. Use sterile technique, and inject the bacteriostatic water against the side of the vial rather than directly onto the cake to avoid mechanical denaturation. Once reconstituted, store at 2-8 °C and use within 30 days for best stability.
Lyophilized vials should be kept refrigerated at 2-8 °C until first use. For long-term storage beyond six months, store at -20 °C in the original sealed vial. Avoid repeated freeze-thaw cycles.
Kit contents
- 10 × 10iu vials of lyophilized recombinant HGH (191AA / somatropin)
- 1 × certificate of analysis (lot-specific)
- 1 × handling and reconstitution insert
Frequently asked questions
Is this product for human consumption?
No. This product is sold strictly for laboratory research use only. It is not a drug, food, cosmetic, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.
What does “191AA” mean and how does it differ from 192AA?
The 191AA designation indicates the full-length human growth hormone sequence (191 amino acids), structurally identical to the endogenous pituitary molecule. Older expression systems sometimes produced a 192AA variant carrying an additional N-terminal methionine artifact; the 191AA preparation is the modern standard for research use.
Do you ship internationally?
This SKU ships from our Canadian fulfillment facility to addresses within Canada. International availability varies by region — see our shipping policy for current routing.
What is the shelf life of an unopened vial?
Properly stored at 2-8 °C in the original sealed vial, lyophilized recombinant HGH retains potency for 24 months from the date of manufacture. The expiration date is printed on each vial.
