What exactly is Glutathione, and why do research programs pick the 1500mg tier?
Glutathione is the principal endogenous tripeptide antioxidant — γ-glutamyl-cysteinyl-glycine — studied in vitro for redox homeostasis, GSH/GSSG cycling, and Phase II conjugation. Compared with the sub-100mg peptides in this catalogue, the 1500mg per vial tier is deliberately high-mass because glutathione is dosed at millimolar concentrations in most cell-culture and biochemical assays, and low-mass vials would exhaust well before a study arm concluded.
What does this specific lot’s CoA cover?
Purity of the reduced (GSH) form is assessed by reverse-phase HPLC with post-column derivatisation, and identity is confirmed by LC-MS against the 307.3 Da theoretical mass. Because oxidised glutathione (GSSG) content is meaningful to redox research, the CoA also reports the reduced-to-oxidised ratio for the release lot.
How do I reconstitute a 1500mg Glutathione vial?
- Bring the vial to room temperature.
- Wipe the rubber stopper with an alcohol swab.
- Add 5 to 10 mL of bacteriostatic water in a steady pour along the vial wall — the higher volume reflects the elevated peptide mass.
- Invert the vial gently for a minute or two; the powder dissolves readily but should not be aerated by shaking.
- Refrigerate at 2 to 8 °C and use within 30 days; glutathione is oxidation-sensitive, so minimise air exposure at each draw.
Why is 1500mg per vial useful for glutathione research?
Because glutathione operates at millimolar intracellular concentrations, most in-vitro exposure and cell-culture protocols call for far more mass per assay than a typical peptide vial provides. A single 1500mg vial sustains multi-well, multi-replicate designs — including redox-cycling experiments where GSH is regenerated across time points — without forcing a fresh reconstitution mid-run.
How does Glutathione compare with N-acetyl cysteine (NAC) in redox studies?
Glutathione is the endpoint antioxidant tripeptide itself, whereas NAC is a cysteine prodrug that supplies the rate-limiting substrate for endogenous GSH synthesis. Programs studying pathway upstream steps often pair the two so that intracellular GSH pools can be either supplemented directly or built biosynthetically.
What ships in the box, and how fast?
- 10 lyophilized Glutathione vials at 1500mg each
- Lot CoA including reduced/oxidised ratio
For laboratory research use only. British Columbia dispatch; Canadian delivery typically 2 to 4 business days after ship notification.
