What exactly is KPV, and why do research programs pick the 5mg tier?
KPV is the Lys-Pro-Val tripeptide corresponding to the C-terminal fragment of α-melanocyte-stimulating hormone, studied in pre-clinical models of NF-κB-mediated inflammatory signalling and epithelial barrier response. The 5mg per vial tier is the entry point for small-cohort screens, protocol development, and any program characterising KPV response curves before committing to a larger design.
What does this specific lot’s CoA cover?
Each KPV lot is released after reverse-phase HPLC characterisation and LC-MS identity confirmation against the 342.5 Da theoretical mass. Lot certificates are catalogued to the product record as they clear release.
How do I reconstitute a 5mg KPV vial?
- Allow the vial to reach room temperature before opening.
- Sanitise the rubber septum with an isopropyl swab.
- Add 1 mL of bacteriostatic water in a slow trickle down the vial wall so the cake stays intact until dilution reaches it.
- Rotate the vial gently — no vortexing — until the solution is clear.
- Store the reconstituted vial refrigerated at 2 to 8 °C and use within 30 days.
Should I order the 5mg or 10mg tier?
The 5mg tier is scaled for exploratory work: a single vial covers a small cohort at typical in-vitro working concentrations without leftover material aging past the 30-day post-reconstitution window. The 10mg tier is the better choice once a program has locked its target concentration and is running multi-arm designs where the extra mass will actually be drawn down.
How does KPV compare with the parent α-MSH sequence?
Full-length α-MSH is a 13-residue melanocortin ligand active across several MC receptors, while KPV is the terminal tripeptide reported in the literature to retain the anti-inflammatory arm without engaging the pigmentation-associated melanocortin signalling. That decoupling is a large part of KPV’s appeal in NF-κB pathway research.
What ships in the box, and how fast?
- 10 lyophilized KPV vials at 5mg each
For laboratory research use only. Same-day British Columbia dispatch when the order is placed before 14:00 PT; Canadian delivery typically lands in 2 to 4 business days after ship notification.
