What exactly is 5-Amino-1MQ, and where does the 50AM tier fit?
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), studied in pre-clinical metabolic and adipocyte models. It is not a peptide — it is a small-molecule NNMT inhibitor, catalogued here for the metabolic and NAD+-salvage-pathway research programs it supports. The 50AM 50mg per vial tier is the standard research presentation for 5-Amino-1MQ. Note: because it is a small molecule (not a peptide), the mechanistic framing throughout is NNMT-inhibition rather than receptor-agonist activity.
What does this specific lot’s CoA cover?
Every lot is independently assayed by reverse-phase HPLC for purity and by mass-spec for identity against theoretical mass. Lot-specific certificates of analysis are being catalogued and will be publicly listed on the product page as they come online.
How do I reconstitute a 50mg 5-Amino-1MQ vial?
- Wipe the vial stopper with an alcohol swab.
- Draw 2 to 5 mL of bacteriostatic water (target concentration determines volume — small molecules typically dissolve cleanly across this range).
- Inject the diluent slowly against the vial wall.
- Swirl gently to dissolve. Small molecules generally require less agitation than peptide cakes.
- Store the reconstituted vial at 2 to 8 °C. Use within 30 days.
Do you sell a smaller vial size?
50mg per vial is currently the only 5-Amino-1MQ presentation stocked. Smaller sizes were considered during SKU planning but 50mg was chosen because it suits the majority of 90-day study designs at conventional working concentrations without needing to reconstitute a fresh vial mid-study. Downstream dilution handles any smaller-dose work.
How does 5-Amino-1MQ differ from NAD+ in a research program?
Both live on the NAD+ axis, but at different mechanistic nodes. NAD+ (NJ500) is a direct substrate — the coenzyme itself, consumed by sirtuins and PARPs. 5-Amino-1MQ acts upstream: it blocks NNMT-mediated methylation of nicotinamide, an enzymatic node in the NAD+ salvage pathway. Inhibiting NNMT preserves nicotinamide for the NAD+-salvage arm rather than shunting it to the methylated metabolite MNAM. Programs that model NAD+ directly use NAD+; programs modelling salvage-pathway flux frequently use 5-Amino-1MQ. Both often appear in the same longer-arc research plan.
What ships in the box, and how fast?
- 10 lyophilized 5-Amino-1MQ 50mg vials
- 1 lot-specific certificate of analysis (HPLC + MS)
- 1 handling and reconstitution insert
Orders placed before 14:00 PT ship the same business day from our British Columbia facility. Canadian orders arrive in 2 to 4 business days after dispatch.
