Product overview
PT-141 10mg/10vials is a sterile lyophilized research peptide. PT-141 (bremelanotide) is a synthetic cyclic heptapeptide and an active metabolite of Melanotan-2 from which the C-terminal amide has been removed. It is studied as a non-selective melanocortin-receptor agonist with notable activity at the central MC4R receptor, and has a substantial preclinical literature on MC4R-mediated CNS endpoints.
Independently assayed by HPLC and MS, and lot-traceable to the source preparation.
Mechanism
PT-141 binds across the melanocortin-receptor family, with significant activity at MC1R, MC3R, MC4R, and MC5R. The molecule is distinguished from its parent compound Melanotan-2 by the absence of the C-terminal amide, which alters receptor-binding kinetics and downstream pharmacology — notably, PT-141 does not produce the pigmentation activity profile of MT-2 and instead has a CNS-leaning pharmacology dominated by MC4R activity.
In preclinical models, MC4R activation in hypothalamic nuclei has been characterized for downstream effects on autonomic tone, neurovascular signaling, and appetite. The molecule has been included in long-running CNS-pharmacology research programs.
Typical research dose range
Published preclinical CNS-pharmacology protocols use PT-141 in animal models in the range of roughly 0.5-2 mg per administration, with timing keyed to the specific endpoint under investigation. Researchers should consult source literature for the specific endpoint and model organism.
Stack and pairing
PT-141 is studied alongside Melanotan-2 in comparative melanocortin-receptor pharmacology work, where the two molecules provide a contrast between pigmentation-leaning (MT-2) and CNS-leaning (PT-141) downstream profiles despite their shared receptor family.
Reconstitution and storage
Reconstitute each vial with 1-2 mL of bacteriostatic water for the target working concentration. Use sterile technique. Once reconstituted, store at 2-8 °C and use within 30 days for best stability.
Lyophilized vials should be kept refrigerated at 2-8 °C until first use. For long-term storage beyond six months, store at -20 °C in the original sealed vial. Avoid repeated freeze-thaw cycles.
Kit contents
- 10 × 10mg vials of lyophilized PT-141
- 1 × certificate of analysis (lot-specific)
- 1 × handling and reconstitution insert
Frequently asked questions
Is this product for human consumption?
No. This product is sold strictly for laboratory research use only. It is not a drug, food, cosmetic, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.
How does PT-141 relate to Melanotan-2?
PT-141 is an active metabolite of Melanotan-2 with the C-terminal amide removed. The two molecules share the melanocortin-receptor family but differ in their downstream pharmacology profile — PT-141 has a more CNS-leaning activity profile dominated by MC4R, while MT-2 produces stronger MC1R-mediated pigmentation effects.
Do you ship internationally?
This SKU ships from our Canadian fulfillment facility to addresses within Canada. International availability varies by region — see our shipping policy for current routing.
What is the shelf life of an unopened vial?
Properly stored at 2-8 °C in the original sealed vial, lyophilized PT-141 retains potency for 24 months from the date of manufacture. The expiration date is printed on each vial.
